Aminoalkyl-substituted benzoxazine derivatives

ABSTRACT

Racemic and optically active compounds of the formula 
     
         Q--C.sub.n H.sub.2n --NH--R 
    
     wherein Q is ##STR1## where R 1  is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino, 
     R 2  is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl, 
     R 1  and R 2 , together with each other, are methylenedioxy or ethylenedioxy, and 
     A is --O--, --CH 2  --CH 2  --, --O--CH 2  -- where the oxygen is bonded to the benzene ring, or --NR 3  -- where R 3  is hydrogen or alkyl of 1 to 4 carbon atoms, 
     N is an integer from 2 to 6, inclusive, and 
     R is hydrogen, benzyl or ##STR2## where R 4  is hydrogen, methyl or ethyl, 
     R 5 , r 6  and R 7 , which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR 3 , --CONHOH, --COOR 3 , R 8  O--, methylsulfonylmethyl or, when one or two of R 5  through R 7  are other than halogen or trifluoromethyl, also --NR 3  R 9 , 
     where 
     R 3  has the meanings defined above, 
     R 8  is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms or aralkyl, and 
     R 9  is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 to 5 carbon atoms, and 
     R 5  and R 6 , together with each other, are --O--CH 2  --O, --O--CH 2  --CH 2  --O--, --CH═CH--CH═CH--, --O--CH 2  --CONH--, --CH 2  --CH 2  --CONH-- or --O--CO--NH--, 
     and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as vasodilators and CNS-stimulators.

This invention relates to novel aminoalkyl-substituted heterocycles and non-toxic salts thereof, as well as to various methods of preparing these compounds.

More particularly, the present invention relates to a novel class of aminoalkyl-substituted heterocycles represented by the formula

    Q--C.sub.n H.sub.2n --NH--R                                (I)

wherein Q is ##STR3## where R₁ is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,

R₂ is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl,

R₁ and R₂, together with each other, are methylenedioxy or ethylenedioxy, and

A is --O--, --CH₂ --CH₂ --, --O--CH₂ -- where the oxygen is bonded to the benzene ring, or --NR₃ -- where R₃ is hydrogen or alkyl of 1 to 4 carbon atoms,

n is an integer from 2 to 6, inclusive, and

R is hydrogen, benzyl or ##STR4## where R₄ is hydrogen, methyl or ethyl,

R₅, r₆ and R₇, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR₃, --CONHOH, --COOR₃, R₈ O--, methylsulfonylmethyl or, when one or two of R₅ through R₇ are other than halogen or trifluoromethyl, also --NR₃ R₉,

where

R₃ has the meanings defined above,

R₈ is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms or aralkyl, and

R₉ is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 to 5 carbon atoms, and

R₅ and R₆, together with each other, are --O--CH₂ --O, --O--CH₂ --CH₂ --O--, --CH═CH--CH═--, --O--CH₂ --CONH--, --CH₂ --CH₂ --CONH-- or --O--CO--NH--,

and non-toxic, pharmacologically acceptable acid addition salts thereof.

The alkylene chain --C_(n) H_(2n) -- in formula I may be straight or branched, and preferred embodiments thereof are --CH₂ --CH₂ --, --CH₂ --CH₂ --CH₂ --, --CH₂ --C(CH₃)₂ -- and primarily --CH₂ --CH₂ --C(CH₃)₂ --, where the tertiary carbon atom is bonded to the nitrogen atom of the --NH--R moiety.

A subgenus thereunder is constituted by compounds of the formula I, wherein

Q, a and R₃ have the meanings previously defined,

R₁ is hydrogen, methoxy or amino,

R₂ is hydrogen or methoxy,

n is an integer from 3 to 6, inclusive,

R is hydrogen or ##STR5## R₅ is hydrogen, --OR₈, --NHR₉, hydroxymethyl, cyano, --CONHR₃ or halogen,

R₆ is hydrogen, hydroxyl or halogen,

R₇ is hydrogen, chlorine, methyl or methoxy,

R₈ is hydrogen, benzyl, methyl or alkanoyl, and

R₉ is hydrogen, formyl, acetyl, methylsulfonyl, carbamoyl or dimethylsulfamoyl,

provided that, when R₆ and/or R₇ are halogen, R₅ is other than --NHR₉ ; and non-toxic, pharmacologically acceptable acid addition salts thereof.

A particularly preferred subgenus thereunder is constituted by compounds of the formula I, wherein

Q, a, r₃, r₄ and n have the meanings previously defined,

R₁ is hydrogen, methoxy or amino,

R₂ is hydrogen or methoxy,

R is hydrogen or ##STR6## R₅ is hydrogen or hydroxyl, R₆ is hydrogen, hydroxyl, hydroxymethyl, cyano, --CONHR₃, --OR₈ or chlorine,

R₅ and R₆, together with each other, are --CH═CH--CH═CH--, --OCH₂ --CONH--, --CH₂ --CH₂ --CONH-- or --O--CONH--,

R₇ is hydrogen, methyl, methoxy, hydroxyl or chlorine, and

R₈ is hydrogen, benzyl or lower alkanoyl,

and non-toxic, pharmacologically acceptable acid addition salts thereof.

The compounds embraced by formula I may be prepared by the following methods, all of which involve known organic synthesis principles:

Method A

For the preparation of a compound of the formula I wherein R is a grouping of the formula III, by reacting an amine of the formula

    Q--C.sub.n H.sub.2n --NH.sub.2                             (IV)

wherein Q and n have the same meanings as in formula I, with a compound of the formula ##STR7## wherein R₅, R₆ and R₇ have the same meanings as in formula I,

and

R₁₀ is hydrogen or alkyl,

under reductive amination conditions. Suitable reducing agents are complex hydrides, preferably sodium borohydride, or hydrogen in the presence of a hydrogenation catalyst, preferably platinum, palladium or nickel.

Method B

For the preparation of a compound of the formula I wherein R is a grouping of the formula III, by reducing a compound of the formula ##STR8## wherein Q, n, R₄, R₅, R₆ and R₇ have the same meanings as in formula I, with a complex hydride, in particular sodium borohydride, or by catalytic hydrogenation with a conventional hydrogenation catalyst, for example, platinum, palladium or nickel.

Method C

For the preparation of a compound of the formula I, wherein R is a grouping of the formula III, by reacting an epoxide of the formula ##STR9## wherein R₄, R₅, R₆ and R₇ have the same meanings as in formula I, with an amine of the formula IV; or by reacting a halohydrin of the formula ##STR10## wherein R₄, R₅, R₆ and R₇ have the same meanings as in formula I, and

Hal is halogen,

with an amine of the formula IV in the presence of an acid binding agent, such as potassium carbonate, sodium carbonate or an excess of the amine IV. The halohydrin of the formula VIII converts into the corresponding epoxide VII under the reaction conditions.

Method D

For the preparation of a compound of the formula I wherein --C_(n) H_(2n) -- is ##STR11## where n has the same meanings as in formula I, and

R₁₁ is hydrogen or methyl,

by reductive amination of a compound of the formula ##STR12## wherein Q and n have the same meanings as in formula I, and

R₁₁ has the meanings defined above, with an amine of the formula

    H.sub.2 N--R                                               (X)

wherein R has the same meanings as in formula I. Suitable reducing agents are complex hydrides, such as sodium borohydride, or hydrogen in the presence of a catalyst, such as platinum, palladium or nickel; or by reducing a compound of the formula ##STR13## wherein Q, n, R₄ and R have the meanings previously defined.

Method E

For the preparation of a compound of the formula I wherein R is a grouping of the formula III, by removing the --CH₂ --aryl protective group from a compound of the formula ##STR14## wherein Q, n, R₄, R₅, R₆ and R₇ have the same meanings as in formula I, by catalytic hydrogenation with a catalyst such as platinum, palladium or nickel.

Method F

For the preparation of a compound of the formula I in which at least one of substituents R₅, R₆ and R₇ is hydroxyl, by removing the arylmethyl protective group or groups from a corresponding compound wherein the respective hydroxyl substituent or substituents are arylmethylated. The removal of the arylmethyl group or groups is effected by catalytic hydrogenation with a catalyst such as platinum, palladium or nickel, or by ether cleavage with a hydrohalic acid or boron tribromide.

Method G

For the preparation of a compound of the formula I wherein R₅ is --NH-acyl or --NH--CO--NH₂, by reacting a compound of the formula ##STR15## wherein Q, n, R₄, R₆ and R₇ have the same meanings as in formula I, and

X is an anion,

with a carboxylic acid anhydride for introduction of the acyl radical, or with a cyanate and an acid for introduction of the carbamoyl radical. At least one mol of an acid, which protects the secondary amino group by salt formation, is additionally required.

Method H

For the preparation of a compound of the formula I wherein R₅ is --CONHR₃, --CONHNH₂ or --CONHOH, by reacting an ester of the formula ##STR16## wherein Q, n, R₄, R₆ and R₇ have the same meanings as in formula I, and

R" is alkyl or substituted alkyl,

with a compound of the formula

    NH.sub.2 --R.sub.12                                        (XV)

wherein R₁₂ is hydrogen, lower alkyl, hydroxyl or amino.

Method I

For the preparation of a compound of the formula I wherein R is hydrogen or benzyl, by removing the protective group or groups from a compound of the formula ##STR17## wherein Q and n have the same meanings as in formula I,

R₁₃ is arylmethyl, acyl or --COOR₁₅,

R₁₄ is hydrogen or benzyl, and

R₁₃ and R₁₄, together with each other, are a dicarboxylic acid radical, such as succinyl or phthalyl, or --CHR₁₅ --,

where R₁₅ is alkyl, arylmethyl or aryl.

When R₁₃ is acyl or --COOR₁₅, or R₁₃ and R₁₄ together are a dicarboxylic acid radical or --CHR₁₅ --, the protective groups are removed by hydrolysis. When R₁₃ and R₁₄ together are a dicarboxylic acid radical, such as phthalyl, the removal may be effected by ring cleavage with hydrazine, followed by hydrolysis. When R₁₃ and/or R₁₄ are arylmethyl, the removal must be effected by hydrogenation in the presence of a catalyst, such as platinum, palladium or nickel. It is also possible to remove the protective group by catalytic hydrogenation when R₁₅ in --COOR₁₅ is arylmethyl.

Method J

For the preparation of a compound of the formula I wherein R is hydrogen, by reducing the nitro group in a compound of the formula

    Q--C.sub.n H.sub.2n --NO.sub.2                             (XVII)

wherein Q and n have the same meanings as in formula I, preferably by catalytic hydrogenation with conventional catalysts, such as nickel.

The starting compounds for methods A through J are either known compounds or may be prepared by known methods.

In those instances where the end products of methods A through J are racemates, these may be separated into the optical antipode components by conventional methods.

The compounds embraced by formula I are organic bases and therefore form acid addition salts with inorganic or organic acids. Examples of non-toxic, pharmacologically acceptable acid addition salts are those formed with hydrochloric acid, hydrobromic acid, sulfuric acid, maleic acid, succinic acid, formic acid, p-amino-benzoic acid, methanesulfonic acid, 8-chlorotheophylline or the like.

The following examples illustrate the present invention and will enable others skilled in the art to understand it more completely. It should be understood, however, that the invention is not limited solely to the particular examples given below.

EXAMPLE I

A mixture consisting of 5.36 gm of 3,4-dichlorophenyl-glyoxal hydrate, 4.5 gm of 1-(3-amino-n-propyl)-1,2,3,4-tetrahydro-quinolone-(2) and 200 ml of ethanol was heated at 50° C. for 1 hour. Then, while cooling, it was admixed with 5 gm of sodium borohydride at 0° to 5° C., the mixture was stirred for 2 hours at room temperature and then acidified with hydrochloric acid, the ethanol was distilled off, and the residue was made alkaline with ammonia. 5.5 gm of the free base, m.p. 95° C., of the formula ##STR18## were obtained. Its hydrochloride, m.p. 185° C., was obtained by admixing the free base with the calculated amount of ethereal hydrochloric acid.

EXAMPLE 2

A mixture consisting of 11 gm of 1-(3,4-dibenzyloxyphenyl)-1-oxo-2-hydroxy-2-ethoxyethane (m.p. 114° C.), 5.6 gm of 1-(3,3-dimethyl-3-amino-n-propyl)-benzimidazolinone-(2) and 225 ml of ethanol was heated for 3 hours and subsequently admixed at 0° to 5° C. with 8 gm of sodium borohydride. The resulting solution was allowed to stand at room temperature for 12 hours, and then acidified with hydrochloric acid and worked up at described in the preceding example. 12.7 gm of free base, m.p. 130° C., of the formula ##STR19## were obtained. Its maleate, m.p. 197° C., was obtained by adding a solution of maleic acid in acetonitrile to the base.

Using procedures and starting compounds analogous to those described in Examples 1 and 2, the compounds shown in the following table were also prepared. The indicated yields are in % of theory.

                                      TABLE I                                      __________________________________________________________________________                                                   Yield                                                                          %   M.P.                                                                       of  of       m.p. of             Ex.                                           theo-                                                                              Base     Salt                No.                                                                               Formula                                    ry  °C.                                                                         Salt °C.          __________________________________________________________________________      3                                                                                 ##STR20##                                 82  115                           4                                                                                 ##STR21##                                 66      maleate                                                                             134                  5                                                                                 ##STR22##                                 81      maleate                                                                             217                  6                                                                                 ##STR23##                                 78  151                           7                                                                                 ##STR24##                                 79      succinate                                                                            94                  8                                                                                 ##STR25##                                 88      p-amino- benzoate                                                                   166                  9                                                                                 ##STR26##                                 60   93                          10                                                                                 ##STR27##                                 75  170 methane- sulfonate                                                                  185                 11                                                                                 ##STR28##                                 78  amor- phous                  12                                                                                 ##STR29##                                 74      hydro- chloride                                                                     194                 13                                                                                 ##STR30##                                 88      hydro- chloride                                                                     215                 14                                                                                 ##STR31##                                 84      maleate                                                                             209                 15                                                                                 ##STR32##                                 66      succinate                                                                           168                 16                                                                                 ##STR33##                                 66      sulfate                                                                             250                 17                                                                                 ##STR34##                                 88  135                          18                                                                                 ##STR35##                                 66  126                          19                                                                                 ##STR36##                                 69.5                                                                               134                          20                                                                                 ##STR37##                                 72      hydro- chloride                                                                     252                 21                                                                                 ##STR38##                                 87      sulfate                                                                             225                 22                                                                                 ##STR39##                                 80      p-amino- benzoate                                                                   123                 23                                                                                 ##STR40##                                 68      sulfate                  24                                                                                 ##STR41##                                 82      hydro- chloride                                                                     215                 25                                                                                 ##STR42##                                 93   93                          26                                                                                 ##STR43##                                 82      sulfate                                                                             183                 27                                                                                 ##STR44##                                 80   68                          28                                                                                 ##STR45##                                 61      maleate                                                                             137                 29                                                                                 ##STR46##                                 81      maleate                                                                             123                 30                                                                                 ##STR47##                                 70      hydro- chloride                                                                     193                 31                                                                                 ##STR48##                                 78      p-amino- benzoate                                                                   118                 32                                                                                 ##STR49##                                 73  178 maleate                                                                             161                 33                                                                                 ##STR50##                                 62      succinate                                                                           198                 34                                                                                 ##STR51##                                 81  139 succinate                                                                           206                 35                                                                                 ##STR52##                                 75  141 maleate                                                                             218                 36                                                                                 ##STR53##                                 69      maleate                                                                             168                 37                                                                                 ##STR54##                                 83      hydro- chloride                                                                     196                 38                                                                                 ##STR55##                                 67      succinate                                                                           180                 39                                                                                 ##STR56##                                 84      maleate                                                                             170                 40                                                                                 ##STR57##                                 69      hydro- chloride                                                                     170                 41                                                                                 ##STR58##                                 79      hydro- chloride                                                                     116                 42                                                                                 ##STR59##                                 70      maleate                                                                             210                 43                                                                                 ##STR60##                                 68      hydro- chloride                                                                     239                 44                                                                                 ##STR61##                                 50      p-amino- benzoate                                                                   152.5               45                                                                                 ##STR62##                                 53      p-amino- benzoate                                                                   159                 46                                                                                 ##STR63##                                 38  163 hydro- chloride                                                                     148                 47                                                                                 ##STR64##                                 86      hydro- chloride                                                                     183                 48                                                                                 ##STR65##                                 88.5                                                                               116                          49                                                                                 ##STR66##                                 95.4                                                                               122                          50                                                                                 ##STR67##                                 84.5    hydro- chloride                                                                     197                 51                                                                                 ##STR68##                                 86      hydro- chloride                                                                     142                 52                                                                                 ##STR69##                                 83      hydor- chloride                                                                     176                 53                                                                                 ##STR70##                                 77  107                          54                                                                                 ##STR71##                                 64      hydro- chloride                                                                     233                 55                                                                                 ##STR72##                                 75      maleate                                                                             218                 56                                                                                 ##STR73##                                 70.3    hydro- chloride                                                                     196                 57                                                                                 ##STR74##                                 70.3    hydro- chloride                                                                     181                 58                                                                                 ##STR75##                                 62      sulfate                                                                             259                 59                                                                                 ##STR76##                                 89  122 hydro- chloride                                                                     172                 60                                                                                 ##STR77##                                 87  108 maleate                                                                             242                 61                                                                                 ##STR78##                                 83  127 hydro- chloride                                                                     220                 62                                                                                 ##STR79##                                 88  137 methane- sulfonate                                                                  170                 63                                                                                 ##STR80##                                 79  183 hydro- chloride                                                                     198                 64                                                                                 ##STR81##                                 68  116 sulfate                                                                             248                 65                                                                                 ##STR82##                                 86      Formate                                                                             143                 66                                                                                 ##STR83##                                 78  112- 114                                                                           hydro- chloride                                                                H.sub.2 O                                                                           227- 228            67                                                                                 ##STR84##                                 71   84                          68                                                                                 ##STR85##                                 73      hydro- chloride                                                                     197                 69                                                                                 ##STR86##                                 79  168 maleate  88              70                                                                                 ##STR87##                                 73      hydro- chloride 187      71                                                                                 ##STR88##                                 69      hydro- chloride                                                                     de- comp.                                                                      >200°        72                                                                                 ##STR89##                                                                  73                                                                                 ##STR90##                                                                  74                                                                                 ##STR91##                                                                  75                                                                                 ##STR92##                                                                  76                                                                                 ##STR93##                                                                  77                                                                                 ##STR94##                                                                  78                                                                                 ##STR95##                                                                  79                                                                                 ##STR96##                                                                  80                                                                                 ##STR97##                                                                  81                                                                                 ##STR98##                                                                  82                                                                                 ##STR99##                                                                  83                                                                                 ##STR100##                                                                 __________________________________________________________________________

example 84

a mixture consisting of 42.5 gm of 3,4-dibenzyloxyphenyl-ω-bromoacetophenone, 29 gm of N-methyl-N'-(2-benzylamino-ethyl)-benzimidazolinone-(2), 25 gm of sodium carbonate and 600 ml of acetonitrile was refluxed for 2 hours. Thereafter, the precipitated inorganic products were filtered off, and the solvent was distilled out of the filtrate under a water aspirator vacuum in a rotary evaporator, the residue was taken up in 900 ml of methanol, 30 ml of an ethereal 12% hydrochloric acid solution and 15 ml of an ethereal 1% palladium chloride solution were added, and the mixture was hydrogenated in the presence of 2 gm of activated charcoal at 60° C. and 6 atmospheres until 3 molar equivalents of hydrogen had been absorbed. After separation of the catalyst, about half of the methanol was distilled off, and the residual solution was admixed with 500 ml of acetonitrile. 32 gm of 1-(3,4-dihydroxyphenyl)-1-oxo-2-[(3-methyl)-benzimidazolinone-(2)-yl]-ethylaminoethane hydrochloride crystallized out which, after recrystallization from water, has a melting point of 250° C. 8 gm of this aminoketone were hydrogenated in 400 ml of methanol in the presence of 1 gm of platinum oxide under standard conditions until 1 molar equivalent of hydrogen had been absorbed, and the hydrogenation product was isolated as its hydrochloride of the formula ##STR101## having a melting point of 185° C. The yield was 88% of theory.

Using an analogous procedure and corresponding starting compounds, the compounds shown in the following table were also prepared:

                                      Table II                                     __________________________________________________________________________                                                Yield                                                                              m.p. of     m.p. of             Ex.                                        % of                                                                               Base        Salt                No.                                                                                 Formula                               theory                                                                             °C.                                                                          Salt   °C.          __________________________________________________________________________      85                                                                                ##STR102##                             89      p-amino- benzoate                                                                      161                  86                                                                                ##STR103##                             92      maleate 134                  87                                                                                ##STR104##                             92      maleate 209                  88                                                                                ##STR105##                             93      succinate                                                                              168                  89                                                                                ##STR106##                             90      maleate 168                  90                                                                                ##STR107##                             96      maleate 210                  91                                                                                ##STR108##                             93      hydrochloride                                                                          239                  92                                                                                ##STR109##                             94      p-amino- benzoate                                                                      159                  93                                                                                ##STR110##                             88      hydrochloride                                                                          170                  94                                                                                ##STR111##                             89      succinate                                                                              204                  95                                                                                ##STR112##                             78      cyclamate                                                                              176                  96                                                                                ##STR113##                             93  170 methane- sulfonate                                                                     185                  97                                                                                ##STR114##                             90      maleate 138                  98                                                                                ##STR115##                             94      maleate H.sub.2                                                                        180                  99                                                                                ##STR116##                             85      maleate 157                 100                                                                                ##STR117##                             92      maleate 180                 101                                                                                ##STR118##                             90      hydrochloride . 2                                                              H.sub.2 O                                                                              275                 102                                                                                ##STR119##                             94      hydrochloride                                                                          265                 103                                                                                ##STR120##                             93      hydrochloride                                                                          177                 104                                                                                ##STR121##                             89      succinate                                                                              215                 105                                                                                ##STR122##                             92      succinate . H.sub.2                                                                    128                 106                                                                                ##STR123##                             94      p-amino- benzoate                                                                      166                 107                                                                                ##STR124##                             91      succinate                                                                              169-71              108                                                                                ##STR125##                             90      p-amino- benzoate                                                                      193                 109                                                                                ##STR126##                             84      succinate                                                                              176                 110                                                                                ##STR127##                             90  212 p-amino- benzoate                                                                      234                 111                                                                                ##STR128##                             92  148 p-amino- benzoate                                                                      191                 112                                                                                ##STR129##                             90      hydrochloride                                                                          190                 113                                                                                ##STR130##                             89      succinate                                                                              189                 114                                                                                ##STR131##                             90      Formiate  .                                                                    1/2CH.sub.3 CN                                                                         159                 115                                                                                ##STR132##                             93   95 hydrochloride                                                                          185                 116                                                                                ##STR133##                             94      hydrochloride                                                                          198                 117                                                                                ##STR134##                             93      p-amino- benzoate                                                                      199                 118                                                                                ##STR135##                             90      hydrochloride                                                                          175                 119                                                                                ##STR136##                             91  206 hydrochloride                                                                          169                 120                                                                                ##STR137##                             94  200 hydrochloride                                                                          201                 121                                                                                ##STR138##                             85  198 hydrochloride                                                                          157                 122                                                                                ##STR139##                             92      succinate                                                                              198                 123                                                                                ##STR140##                             89      acid maleate                                                                           202                 124                                                                                ##STR141##                             97      acid maleate                                                                           180                 125                                                                                ##STR142##                             92      acid maleate                                                                           168                 126                                                                                ##STR143##                             89      hydrochloride                                                                          230                 127                                                                                ##STR144##                             94      hydrochloride                                                                          252                 128                                                                                ##STR145##                             90      succinate                                                                              173                 129                                                                                ##STR146##                             91  198 hydrochloride                                                                          235                 130                                                                                ##STR147##                             84      succinate                                                                              212                 131                                                                                ##STR148##                             89      succinate                                                                              218                 132                                                                                ##STR149##                             94  180 hydrochloride                                                                          190                 133                                                                                ##STR150##                             88      formate 214                 134                                                                                ##STR151##                             92  190 hydrochloride                                                                          225                 135                                                                                ##STR152##                             87      hydrochloride                                                                          170                 136                                                                                ##STR153##                             90  193 hydrochloride                                                                          196                 137                                                                                ##STR154##                             96      maleate 210                 138                                                                                ##STR155##                             96      hydrochloride                                                                          239                 139                                                                                ##STR156##                             93      p-amine- benzoate                                                                      152.5               140                                                                                ##STR157##                             90      p-amine- benzoate                                                                      159                 141                                                                                ##STR158##                             67  163 hydrochloride                                                                          148                 142                                                                                ##STR159##                             81       benzoatep-amino-                                                                      190                 143                                                                                ##STR160##                             79      hydrochloride                                                                          262                 144                                                                                ##STR161##                             84      maleate 202                 145                                                                                ##STR162##                             88      maleate 202                 146                                                                                ##STR163##                             85  180 succinate                                                                              203                 147                                                                                ##STR164##                             88       benzoatep-amino-                                                                      196                 148                                                                                ##STR165##                             90  180 hydrochloride                                                                          193                 149                                                                                ##STR166##                             72      hydrochloride                                                                          212                 150                                                                                ##STR167##                             69      hydrochloride                                                                          182                 151                                                                                ##STR168##                             76      hydrochloride                                                                          221                 152                                                                                ##STR169##                             82  113  . H.sub.2 Ohydrochlori                                                        de      80-82               153                                                                                ##STR170##                             79      formate 138                 154                                                                                ##STR171##                             72      methane- sulfonate .                                                           H.sub.2 O                                                                              120                 155                                                                                ##STR172##                             76      hydrochloride                                                                          252                 156                                                                                ##STR173##                             81      sulfate 192                 157                                                                                ##STR174##                             72      hydrochloride                                                                          209                 158                                                                                ##STR175##                                     hydro- chloride .                                                              H.sub.2 O                                                                              173- 176            159                                                                                ##STR176##                             83      hydro- chloride                                                                        amor- phor          160                                                                                ##STR177##                             78  156 hydro- chloride                                                                        188                 161                                                                                ##STR178##                             86      maleate 176                 162                                                                                ##STR179##                             62      hydro- chloride                                                                        de- comp.                                                                      >230                163                                                                                ##STR180##                             57      methane- sulfonate                                                                     de- comp.                                                                      >230                164                                                                                ##STR181##                             67      hydro- chloride                                                                        de- comp.                                                                      >220                165                                                                                ##STR182##                             58      sulfate de- comp.                                                                      >240                166                                                                                ##STR183##                             71      hydro- chloride                                                                        de- comp.                                                                      >230                167                                                                                ##STR184##                             52      hydro- chloride                                                                         de- comp.                                                                     >230                168                                                                                ##STR185##                             67      hydro- chloride                                                                        de- comp.                                                                      >220                169                                                                                ##STR186##                             82      methane- sulfonate                                                                     de- comp.                                                                      >240                170                                                                                ##STR187##                                     hydro- chloride                                                                        de- comp.                                                                      >230                171                                                                                ##STR188##                             61      hydro- chloride                                                                        de- comp.                                                                      >240                172                                                                                ##STR189##                             69      hydro- chloride                                                                        de-comp.            __________________________________________________________________________                                                                >220           

EXAMPLE 173

A solution of 9.1 gm of m-benzyloxy-ω-bromoacetophenone in 75 ml of ethanol was admixed at -5° C. with 1.2 gm of sodium borohydride, and the mixture was stirred for half an hour. The resulting solution was admixed with a little hydrobromic acid, the ethanol was distilled off under reduced pressure, and the residue was taken up in ethyl acetate. The solution was extracted first with an aqueous sodium bicarbonate solution and then with water, dried and evaporated in vacuo. The residue was taken up in 45 ml of dimethylformamide, admixed with 6.57 gm of 1-(4-amino-4,4-dimethylbutyl)-benzimidazolidinone-(2) and 6.65 gm of sodium carbonate, and the mixture was stirred for 6 hours at 105° C. After working up, the reaction product was isolated as its succinate of the formula ##STR190## which had a melting point of 94° C. The yield was 58% of theory.

Using an analogous procedure and corresponding starting compounds, the compounds shown in the following table were also prepared:

                                      Table III                                    __________________________________________________________________________                                                   Yield                                                                              m.p.     m.p.                Ex.                                           % of                                                                               of Base  of Salt             No.                                                                               Formula                                    theory                                                                             °                                                                           Salt °            __________________________________________________________________________                                                                C.                  174                                                                                ##STR191##                                61      p-amino- benzoate                                                                   166                 175                                                                                ##STR192##                                59   68                          176                                                                                ##STR193##                                62      maleate                                                                             210                 177                                                                                ##STR194##                                68      hydro- chloride                                                                     239                 178                                                                                ##STR195##                                76      p-amino- benzoate                                                                   152.5               179                                                                                ##STR196##                                73      p-amino- benzoate                                                                   159                 180                                                                                ##STR197##                                64  122                          181                                                                                ##STR198##                                64      sulfate                                                                             225                 182                                                                                ##STR199##                                47  170 methane- sulfonate                                                                  185                 __________________________________________________________________________

EXAMPLE 183

By reacting 69.6 gm of the compound of the formula ##STR200## with 55.6 gm of chloroacetone in the presence of potassium carbonate and potassium iodide in acetone, followed by acid-catalyzed hydrolysis, 32 gm of the compound of the formula ##STR201## m.p. 182° C. were obtained. A solution of 19 gm of this substance in 300 ml of methanol was admixed with 25 ml of ammonia, and the mixture was hydrogenated with Raney nickel as the catalyst at 50° to 60° C. and 6 atmospheres. The hydrogenation product was isolated as its hydrochloride, m.p. 267°-270° C., of the formula ##STR202## The yield was 15.6 gm.

EXAMPLE 184

A mixture consisting of 35 gm of 3,4-dibenzyloxy-ω-bromoacetophenone, 24 gm of 1-(3-benzylamino-n-propyl)-benzimidazolinone-(2), 22 gm of sodium carbonate and 300 ml of acetonitrile was refluxed for 2 hours. The reaction product of the formula ##STR203## was isolated at its bioxalate with a yield of 44 gm (m.p. 168° C.). The free base (m.p. 112° C.) was liberated with aqueous ammonia. 35 gm of the base were dissolved in 350 ml of ethanol, 29 ml of 2 N sodium hydroxide were added to the solution, and then a total of 6 gm of sodium borohydride were added in portions over a period of 90 minutes. The reaction product of the formula ##STR204## was isolated as the free base (m.p. 93° C.).

A solution of 15 gm of the base in 150 ml of methanol was hydrogenated in the presence of 3 gm of palladized coal at 60° C. and 6 atmospheres until 3 molar equivalents of hydrogen had been absorbed. After removal of the catalyst, the solution was admixed with a solution of 2 gm of succinic acid in 20 ml of hot methanol, yielding 77% of theory of the crystalline succinate, m.p. 204° C., of the formula ##STR205##

Using analogous procedures and starting compounds, the compounds shown in the following table were also prepared:

                                      Table IV                                     __________________________________________________________________________     Ex.                                     Yield %                                                                             m.p. of      m.p. of              No.                                                                               Formula                              of theory                                                                           Base °C.                                                                     Salt    Salt                 __________________________________________________________________________                                                               °C.           185                                                                                ##STR206##                          81   170  methane- sulfonate                                                                     185                  186                                                                                ##STR207##                          77        succinate                                                                              189                  187                                                                                ##STR208##                          62        hydrochloride                                                                          185                  188                                                                                ##STR209##                          91        hydrochloride                                                                          198                  189                                                                                ##STR210##                          82        hydrochloride                                                                          182                  __________________________________________________________________________

EXAMPLE 190

A solution of 7 gm of the compound of the formula ##STR211## in 200 ml of methanol was hydrogenated in the presence of 1 gm of palladized coal under standard conditions until 2 molar equivalents of hydrogen had been absorbed. The hydrogenation product was isolated with a yield of 94% of theory as its maleate (m.p. 180° C., with 1 mol of water of crystallization) of the formula ##STR212##

Using analogous procedures and starting compounds, the compounds shown in the following table were also prepared:

                                      Table V                                      __________________________________________________________________________     Ex.                                      Yield %                                                                             m.p. of     m.p. of              No.                                                                               Formula                               of theory                                                                           Base °C.                                                                     Salt   Salt                 __________________________________________________________________________                                                               °C.           191                                                                                ##STR213##                           91        hydrochloride                                                                         185                  192                                                                                ##STR214##                           92        cyclamate                                                                             176                  193                                                                                ##STR215##                           89        maleate                                                                               134                  194                                                                                ##STR216##                           90        succinate                                                                             204                  195                                                                                ##STR217##                           90        hydrochloride                                                                         170                  196                                                                                ##STR218##                           85        hydrochloride                                                                         158                  197                                                                                ##STR219##                           86        maleate                                                                               168                  198                                                                                ##STR220##                           91        hydrochloride                                                                         265                  199                                                                                ##STR221##                           90        hydrochloride ×                                                          2 H.sub.2 O                                                                           275                  200                                                                                ##STR222##                           85        maleate                                                                               180                  201                                                                                ##STR223##                           91        maleate                                                                               157                  202                                                                                ##STR224##                           94        maleate                                                                               138                  203                                                                                ##STR225##                           83        succinate                                                                             176                  204                                                                                ##STR226##                           93        p-amino- benzoate                                                                     193                  205                                                                                ##STR227##                           92        succinate                                                                             171                  206                                                                                ##STR228##                           93        succinate ×                                                              H.sub.2 O                                                                             128                  207                                                                                ##STR229##                           92        succinate                                                                             215                  208                                                                                ##STR230##                           90        hydrochloride                                                                         177                  209                                                                                ##STR231##                           84        formate                                                                               214                  210                                                                                ##STR232##                           90   190  hydrochloride                                                                         225                  211                                                                                ##STR233##                           82        hydrochloride                                                                         170                  212                                                                                ##STR234##                           93   193  hydrochloride                                                                         196                  213                                                                                ##STR235##                           9         hydrochloride                                                                         175                  214                                                                                ##STR236##                           94   206  hydrochloride                                                                         169                  215                                                                                ##STR237##                           91   200  hydrochloride                                                                         201                  216                                                                                ##STR238##                           86   198  hydrochloride                                                                         157                  217                                                                                ##STR239##                           84        acid maleate                                                                          202                  218                                                                                ##STR240##                           92        acid maleate                                                                          180                  219                                                                                ##STR241##                           92   212  p-amino- benzoate                                                                     234                  220                                                                                ##STR242##                           93   148  p-amino- benzoate                                                                     191                  221                                                                                ##STR243##                           92        hydrochloride                                                                         190                  222                                                                                ##STR244##                           86        succinate                                                                             189                  223                                                                                ##STR245##                           84        formate × 1/2                                                            CH.sub.3 CN                                                                           159                  224                                                                                ##STR246##                           89        hydrochloride                                                                         198                  225                                                                                ##STR247##                           90        p-amino- benzoate                                                                     199                  226                                                                                ##STR248##                           81        acid maleate                                                                          168                  227                                                                                ##STR249##                           81        hydrochloride                                                                         230                  228                                                                                ##STR250##                           84        hydrochloride                                                                         252                  229                                                                                ##STR251##                           90        succinate                                                                             173                  230                                                                                ##STR252##                           93   198  hydrochloride                                                                         235                  231                                                                                ##STR253##                           85        succinate                                                                             212                  232                                                                                ##STR254##                           82        succinate                                                                             218                  233                                                                                ##STR255##                           84   180  hydrochloride                                                                         190                  234                                                                                ##STR256##                           81        p-amino- benzoate                                                                     190                  235                                                                                ##STR257##                           82   180  succinate                                                                             203                  236                                                                                ##STR258##                           89        p-amino- benzoate                                                                     196                  237                                                                                ##STR259##                           92   180  hydrochloride                                                                         193                  238                                                                                ##STR260##                           82        hydrochloride                                                                         212                  239                                                                                ##STR261##                           79        hydrochloride                                                                         182                  240                                                                                ##STR262##                           79        hydrochloride                                                                         221                  241                                                                                ##STR263##                           80   113  hydrochloride ×                                                          H.sub.2 O                                                                             80-82                242                                                                                ##STR264##                           75        formate                                                                               138                  243                                                                                ##STR265##                           82        methane- sulfonate                                                             × H.sub.2                                                                       120                  244                                                                                ##STR266##                           86        sulfate                                                                               192                  245                                                                                ##STR267##                           88   173  hydrochloride                                                                         203                  246                                                                                ##STR268##                           73.6 175  hydrochloride                                                                         216                  247                                                                                ##STR269##                           63        hydrochloride                                                                         181                  248                                                                                ##STR270##                           74   169  dihydro- chloride                                                                     206                  249                                                                                ##STR271##                           72                                    250                                                                                ##STR272##                           69        hydro- chloride                                                                       amor- phous          251                                                                                ##STR273##                           87   156  hydro- chloride                                                                       188                  252                                                                                ##STR274##                           75        maleate                                                                               176                  253                                                                                ##STR275##                           74        hydro- chloride                                                                       decomp. >230         254                                                                                ##STR276##                           92        methane- sulfonate                                                                    decomp. >230         255                                                                                ##STR277##                           88        hydro- chloride                                                                       decomp. >220         256                                                                                ##STR278##                           87        sulfate                                                                               decomp. >240         257                                                                                ##STR279##                           78        hydro- chloride                                                                       decomp. >230         258                                                                                ##STR280##                           80        hydro- chloride                                                                       decomp. >230         259                                                                                ##STR281##                           78        hydro- chloride                                                                       decomp.  >220        260                                                                                ##STR282##                           72        methane- sulfonate                                                                    decomp. >240         261                                                                                ##STR283##                           81        hydro- chloride                                                                       decomp, >230         262                                                                                ##STR284##                           69                                    __________________________________________________________________________

example 263

a mixture consisting of 3.9 gm of the compound of the formula ##STR285## 2 gm of acetic acid anhydride and 40 ml of dimethylformamide was heated on a boiling water bath for 1 hour. Thereafter, the solvent was distilled off in vacuo, and the base was liberated with ammonia, taken up in ethyl acetate, and the solution was dried. The ethyl acetate was distilled off, and the base was admixed in acetonitrile with the calculated amount of maleic acid, yielding 3.5 gm of the maleate of the formula ##STR286## which had a melting point of 202° C. after recrystallization from methanol.

EXAMPLE 264

A solution of 6.1 gm of the compound of the formula ##STR287## in a mixture of 20 ml of water and 7.5 ml of glacial acetic acid was admixed with a solution of 1.41 gm of potassium cyanate in 7.5 ml of water at 35° C. After standing overnight, the base was liberated with ammonia, separated by extracting it three times with isobutanol and converted into the maleate of the formula ##STR288## were obtained. After recrystallization from water, it had a melting point of 202° C.

EXAMPLE 265

A mixture consisting of 5 gm of the compound of the formula ##STR289## 100 ml of methanol and 100 ml of a concentrated aqueous ammonia solution was gently heated until a solution had formed. The solution was allowed to stand for an extended period of time, during which 4.3 gm of the base (m.p. 198° C.) of the formula ##STR290## crystallized out. Its hydrochloride, obtained by acidifying an ethanolic solution of the base with hydrochloric acid, had a melting point of 235° C.

Using analogous procedures and corresponding starting compounds, the compounds shown in the following table were also prepared:

                                      Table VI                                     __________________________________________________________________________                                                       m.p.     m.p.                                                              Yield                                                                              of       of                  Ex.                                           % of                                                                               Base     Salt                No.                                                                               Formula                                    theory                                                                             °C.                                                                         Salt °C.          __________________________________________________________________________     266                                                                                ##STR291##                                83  172 hydro- chloride                                                                     204                 267                                                                                ##STR292##                                86  113 hydro- chloride                                                                × H.sub.2                                                                     80-82               268                                                                                ##STR293##                                84  180 hydro- chloride                                                                     190                 269                                                                                ##STR294##                                84      hydro- chloride                                                                     221                 270                                                                                ##STR295##                                91  190 hydro- chloride                                                                     225                 271                                                                                ##STR296##                                86      hydro- chloride                                                                     195                 272                                                                                ##STR297##                                83.5    hydro- chloride                                                                     147                 273                                                                                ##STR298##                                77      hydro- chloride                                                                     178 (de-                                                                       comp.)              274                                                                                ##STR299##                                95      hydro- chloride                                                                     208 (de-                                                                       comp.)              275                                                                                ##STR300##                                90  145 hydro- chloride                                                                     215 (de-                                                                       comp.)              276                                                                                ##STR301##                                88      hydro- chloride                                                                     197 (de-                                                                       comp.)              277                                                                                ##STR302##                                63  157 hydro- chloride                                                                     137                 __________________________________________________________________________

EXAMPLE 278

69.6 gm of the compound of the formula ##STR303## and then a solution of 0.44 mol of 3-(dibenzylamino)-n-propyl chloride in 300 ml of absolute ethanol were added to a solution of 0.42 mol of sodium in 200 ml of absolute ethanol, and the mixture was refluxed for six hours. Thereafter, the precipitated sodium chloride was separated, and the liquid phase was admixed with 45 ml of concentrated sulfuric acid while stirring and cooling. After three hours 700 ml of water were added, the ethanol was distilled off, and the residual solution was made alkaline with ammonia, whereupon the compound of the formula ##STR304## precipitated out. Recrystallized from acetonitrile, the product had a melting point of 146° C.

60 gm of this compound were hydrogenated in a mixture of 400 ml of methanol and 200 ml of water in the presence of 16 ml of concentrated hydrochloric acid and palladized coal at 60° C. and 6 atmospheres until 1 molar equivalent of hydrogen had been absorbed. 88% of theory of the compound of the formula ##STR305## were obtained; it had a melting point of 60° C.

EXAMPLE 279

A solution of 53.4 gm of the compound of the formula ##STR306## in 420 ml of methanol and 80 ml of water was hydrogenated in the presence of 20 ml of concentrated hydrochloric acid and palladized coal at 60° C. and 6 atmospheres until 1 molar equivalent of hydrogen had been absorbed. 91% of theory of the hydrochloride (m.p. 315° C.) of the formula ##STR307## was obtained.

EXAMPLE 280

10.1 gm of sodium hydride and 45 gm of N-(3-chloro-n-propyl)-phthalimide were added to a solution of 31.1 gm of the compound of the formula ##STR308## in 150 ml of hexamethylphosphoric triamide (hexametapol) in an atmosphere of nitrogen, and the mixture was stirred for 5 hours at 100° C. The isolated raw reaction product of the formula ##STR309## was refluxed in 1 liter of ethanol with 13 gm of 85% hydrazine hydrate for 90 minutes, admixed with 21 ml of concentrated hydrochloric acid and 100 ml of water, and heated again for 20 minutes. The precipitated phthalic acid hydrazide was separated by suction filtration, and the hydrochloride (m.p. 195° C. from ethanol) of the formula ##STR310## was isolated.

EXAMPLE 281

3.3 gm of sodium hydride (55%) were added to a solution of 9.2 gm of the compound of the formula ##STR311## in 40 ml of absolute hexamethylphosphoric triamide in an atmosphere of nitrogen, and after the calculated amount of hydrogen had been released, a solution of 3-benzylamino-n-propyl chloride (b.p. 140° C. at 12 mm Hg) in 13 ml of hexamethylphosphoric triamide was added. The resulting mixture was stirred for 5 hours at 100° C., then poured over ice, and the reaction product of the formula ##STR312## was isolated by extraction with ether and hydrolyzed without purification with 2 N hydrochloric acid, yielding 67% of theory of the hydrochloride of the formula ##STR313## which had a melting point of 152°-155° C.

Using analogous procedures and corresponding starting compounds, the compounds shown in the following table were also prepared:

                                      Table VII                                    __________________________________________________________________________     Ex.                                Yield %                                                                             m.p. of   m.p. of                      No.                                                                                 Formula                       of theory                                                                           Base °C.                                                                     Salt Salt °C.              __________________________________________________________________________     282                                                                                ##STR314##                     84.5 175  hydro- chloride ×                                                        H.sub.2 O                                                                           280                          283                                                                                ##STR315##                     54        hydro- chloride                                                                     150                          284                                                                                ##STR316##                     62        maleate                                                                             157                          285                                                                                ##STR317##                     55        hydro- chloride                                                                     214-216                      286                                                                                ##STR318##                     90        hydro- chloride                                                                     277-79                       287                                                                                ##STR319##                     68        hydro- chloride                                                                     237-239                      288                                                                                ##STR320##                     75        hydro- chloride                                                                     266-268                      289                                                                                ##STR321##                     74    76  hydro- chloride ×                                                        H.sub.2 O                                                                              140.5                     290                                                                                ##STR322##                     92   135  hydro- chloride                                                                     306                          291                                                                                ##STR323##                     89        hydro- chloride                                                                     253                          292                                                                                ##STR324##                     65        p-amino- benzoate                                                                   245                          293                                                                                ##STR325##                     70        p-amino benzoate                                                                    225                          294                                                                                ##STR326##                     82        p-amino benzoate                                                                    233                          295                                                                                ##STR327##                     80        hydro- chloride                                                                     267-70                       296                                                                                ##STR328##                     62        maleate                                                                             179                          297                                                                                ##STR329##                     87    81                                    298                                                                                ##STR330##                     75        hydro- chloride                                                                     246                          299                                                                                ##STR331##                     72.3      hydro- chloride                                                                     185                          300                                                                                ##STR332##                     61        hydro- chloride                                                                     225                          301                                                                                ##STR333##                     60        hydro- chloride                                                                     202                          302                                                                                ##STR334##                     89        hydro- chloride                                                                     225                          __________________________________________________________________________

EXAMPLE 303

A solution of 174 gm of the compound of the formula ##STR335## in 700 ml of absolute hexamethylphosphoric triamide was admixed with 48 gm of sodium hydride in the form of a 55% suspension, and after the evolution of hydrogen had ceased, a solution of 341 gm of the compound of the formula ##STR336## (m.p. 76° C.) in 450 ml of hexamethylphosphoric triamide was added. The mixed solution was stirred for 5 hours at 100° C., then poured over ice, extracted with ether, and after evaporation of the ether from the extract the residue was dissolved in 3 liters of ethanol, and the solution was admixed with 300 ml of 5 N sulfuric acid. The next day the reaction product of the formula ##STR337## was isolated with a yield of 61% of theory (m.p. 198° C.). 58.75 gm of this compound were dissolved in 1700 ml of methanol, and after addition of Raney nickel the solution was hydrogenated at 6 atmospheres and 40°-60° C. The compound of the formula ##STR338## was isolated with a yield of 92% of theory (m.p. 135° C.). Its hydrochloride had a melting point of 306° C.

The compounds of the present invention, that is, those embraced by formula I above and their non-toxic, pharmacologically acceptable acid addition salts, have useful pharmacodynamic properties. More particularly, they exhibit coronary dilating and CNS-stimulating activities in warm-blooded animals, such as rats, guinea pigs and dogs, and are therefore useful as antihypertensives, bronchospasmolytics, circulation enhancers and antidepressants.

When R in formula I is a substituent group of the formula III, the nature of the variable substituents on the phenyl moiety thereof has an effect on the predominant pharmacological activity of these compounds.

For example, when R₅, R₆ and R₇ are lipophilic radicals or impart a lipophilic character to the substituent group of the formula III, the antidepressant activity predominates in these compounds. Such is the case, for instance, when R₅, R₆ and R₇ are hydrogen, halogen, alkoxy, amino, alkyl or trifluoromethyl, or when R₇ is hydrogen and R₅ and R₆ together with each other are ethylenedioxy or especially methylenedioxy.

When R₅, R₆ and R₇ are --OR₈ (where R₈ is hydrogen, acyl or aralkyl), --NH-acyl, amino or hydroxymethyl, or when R₅ and R₆ together with each other are --O--CH₂ --CONH--, --CH₂ --CH₂ --CONH-- or --O--CONH-- and R₇ is hydroxyl, the vasodilating activity predominates in these compounds.

Finally, when R₅ is --OR₈ (where R₈ is hydrogen, acyl or aralkyl), R₆ is --CONHR₃ and R₇ is especially hydrogen, the antihypertensive activity predominates in these compounds.

Illustrative of the good pharmacological activity of the compounds of the present invention are the following data, where ##STR339##

Compound B, tested for peripheral vasodilation in dogs by measurement of the blood flow through the left hind extremity after intra-arterial administration, had a 22 times longer effective half-time and was 18 times more effective than the known vasodilator isoxsuprine.

Compound A, tested for antihypertensive activity on awake, genetically hypertonic rats, produced a decrease in blood pressure of 85 mm Hg at a dosage level of 30 mgm/kg i.p.

Compound C, tested for bronchospasmolytic activity in guinea pigs, was found to have a median effective dose ED₅₀ i.v. of 0.09 μgm/kg, whereas the corresponding ED₅₀ -value for the known, highly effective bronchospasmolytic isoproterenol is 3.0 μgm/kg.

For pharmaceutical purposes the compounds according to the present invention are administered to warm-blooded animals perorally, parenterally, rectally or by the inhalation route as active ingredients in customary dosage unit compositions, that is, compositions in dosage unit form consisting essentially of an inert pharmaceutical carrier and one effective dosage unit of the active ingredient, such as tablets, coated pills, capsules, wafers, powders, solutions, suspensions, emulsions, syrups, suppositories, inhalation sprays and the like. One effective dosage unit of the compounds according to the present invention is from 0.016 to 8.33 mgm/kg body weight, preferably 0.033 to 3.3 mgm/kg body weight, depending upon the form or mode of administration and the particular compound. The higher dosages are primarily adapted for sustained release compositions.

The following examples illustrate a few pharmaceutical dosage unit compositions comprising a compound of the present invention as an active ingredient and represent the best modes contemplated of putting the invention into practical use. The parts are parts by weight unless otherwise specified.

EXAMPLES 304 Tablets

The tablet composition is compounded from the following ingredients:

    ______________________________________                                         1-(3,4-Methylenedioxy-phenyl)-2-[1,1-                                          dimethyl-3-(benzimidazolidin-2-one-                                            1-yl)-n-propyl-amino]-ethanol maleate                                          (see Example 55)       2       parts                                           Stearic acid           6       parts                                           Glucose                592     parts                                           Total                  600     parts                                           ______________________________________                                    

Preparation

The ingredients are admixed in conventional manner, and the composition is compressed into 600 mgm-tablets. Each tablet contains 2 mgm of the active ingredient and is an oral dosage unit composition.

EXAMPLE 305 Suppositories

The suppository composition is compounded from the following ingredients:

    ______________________________________                                         1-(3,4-Methylenedioxy-phenyl)-2-[1,1-                                          dimethyl-3-(3-methylbenzimidazolidin-                                          2-one-1-yl)-n-propyl-amino]-ethanol                                            hydrochloride (see Example 63)                                                                          100     parts                                         Lactose, powdered        45      parts                                         Cocoa butter             1555    parts                                         Total                    1700    parts                                         ______________________________________                                    

Preparation

The ingredients are processed in conventional manner into 1700 mgm-suppositories, each of which contains 100 mgm of the active ingredient and is a rectal dosage unit composition.

EXAMPLE 306 Capsules

The capsule filler composition is compounded from the following ingredients:

    ______________________________________                                         1-(3-Carboxymethylamido-4-hydroxyphenyl)-                                      2-[1,1-dimethyl-3-(1,2,3,4-tetrahydro-                                         quinol-2-one-1-yl)-n-propyl-amino]-                                            ethanol hydrochloride (see Example 233)                                                                200      parts                                         Lactose                 440      parts                                         Corn starch             360      parts                                         Total                   1000     parts                                         ______________________________________                                    

Preparation

The ingredients are intimately admixed, the mixture is milled into a powder, and 1000 mgm-portions of the powder are filled into gelatin capsules of suitable size. Each capsule is an oral dosage unit composition containing 200 mgm of the active ingredient.

Any one of the other compounds embraced by formula I or a non-toxic, pharmacologically acceptable acid addition salt thereof may be substituted for the particular active ingredient in Examples 304 through 306. Likewise, the amount of active ingredient in these illustrative examples may be varied to achieve the dosage unit range set forth above, and the amounts and nature of the inert pharmaceutical carrier ingredients may be varied to meet particular requirements.

While the present invention has been illustrated with the aid of certain specific embodiments thereof, it will be readily apparent to others skilled in the art that the invention is not limited to these particular embodiments, and that various changes and modifications may be made without departing from the spirit of the invention or the scope of the appended claims. 

We claim:
 1. A racemic or optically active compound of the formula ##STR340## wherein R₁ is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino;R₂ is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl; R₁ and R₂, together with each other, are methylenedioxy or ethylenedioxy; R₄ is hydrogen, methyl or ethyl; R₅, r₆ and R₇ are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR₃, --CONHOH, --COOR₃, R₈ O--, methylsulfonylmethyl or, when one or two of R₅ through R₇ are other than halogen or trifluoromethyl, also --NR₃ R₉ ; R₃ is hydrogen or alkyl of 1 to 4 carbon atoms; R₈ is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms or aralkyl; R₉ is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 to 5 carbon atoms; R₅ and R₆ together with each other, are --O--CH₂ --O--, --O--CH₂ --CH₂ --O--, --CH═CH--CH═CH--, --CH₂ --CH₂ --CONH-- or --O--CO--NH--; and n is an integer from 2 to 6, inclusive,or a non-toxic, pharmacologically acceptable acid addition salt thereof.
 2. A compound of claim 1, which is of the formula ##STR341## or a non-toxic, pharmacologically acceptable acid addition salt thereof.
 3. A vasodilating or antidepressant pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective vasodilating or antidepressant amount of a compound of claim
 1. 4. The method of dilating the blood vessels or relieving depression in a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective vasodilating or anti-depressant amount of a compound of claim
 1. 